Liquid Chromatography – Mass Spectrometry
Combines LC separation with highly sensitive mass detection for ultra-trace quantification below ppb levels.
LC-MS combines the separation capability of liquid chromatography with highly sensitive mass-based detection, enabling accurate identification and quantification of complex mixtures.
It provides selective detection, often reducing the need for complete chromatographic separation.
How it works
Separation
Liquid chromatography separates mixtures containing multiple components before analysis.
Mass detection
Mass spectrometry identifies components based on their ionised mass-to-charge ratios.
Ionisation interfaces
ESI, APCI, APPI and other API-based techniques enable efficient ionisation.
LC-MS is widely used in pharmaceutical research and development for compound identification and ultra-trace quantification at levels below parts-per-billion (ppb).
At a glance
| Ionisation | ESI · APCI · APPI |
|---|---|
| Sensitivity | Sub-ppb quantification |
| Service | Method development, validation & impurity identification |
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